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KMID : 0367419930360060830
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Journal of Korean Pediatric Society
1993 Volume.36 No. 6 p.830 ~ p.836
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Serum Alkaline Phosphatase Activity after Intravenous Administration of Alnumin Preparation
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허준
안강모/구자욱/하일수/정해일/최용
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Abstract
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Serum alkaline phosphatase (AP) activity is elevated in hepatobiliary disease, bone disease, pregnancy and certain neoplasms. Recently we experienced marked elevation of serum AP activity after administration of albumin preparation in nephrotic
patients
who suffered from hypovolemic symptoms. So serum AP activity and the isoenzymes in the albumin preparations & patient's serum after the administration of albumin preparation were studied. Serum AP activity was significantly higher after
administration
of albumin preparation (318±101 IU/L) then before (123±43 IU/L). The predominant isoenzyme after administration of albumin was placental type, while liver and bone type was predominant before administration. AP activity in albumin preparation
was
high
(2,133±1,410 IU/L) and the isoenzyme was mostly placental type. So we concluded that marked elevation of serum AP activity after administration of albumin was traced to the placental type AP isoenzyme in some albumin preparations which was
manufactured
from the plasma of placental origin.
Elevated serum AP activity like these may lead to erroneous interpretation. Manufactures should notify alkaline phosphatase activity in albumin preparations of placental origin.
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KEYWORD
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